RenalToolBox encourages the use of preprints using servers such as bioRxiv and all our publications and underlying data can be found in our Zenodo community.

• • Skovronova, R., Scaccia, E., Calcat-i-Cervera, S., Bussolati, B., O’Brien, T., Bieback, K. Adipose stromal cells bioproducts as cell-free therapies: manufacturing and therapeutic dose determine in vitro functionality. Journal of Translational Medicine (2023), 21, 723. Link to paper.
  • da Silva, T.B., Rendra, R., David, C.A.W., Bieback, K., Cross, M.J., Wilm, B., Liptrott, N.J., Murray, P. Umbilical cord mesenchymal stromal cell-derived extracellular vesicles lack the potency to immunomodulate human monocyte-derived macrophages in vitro. Biomedicine & Pharmacotherapy (2023), 167, 115624. Link to paper.
  • Luchian, A., Cepeda, K.T., Harwood, R., Lu, J., Murray, P., Wilm, B., Kenny, S., Pregel, P., Ressel, L. Quantifying acute kidney injury in an Ischaemia-Reperfusion Injury mouse model using Deep Learning-based semantic segmentation in histology. Biology Open (2023), in Print. Link to paper.
  • Ahmed, S., de Vries, J., Lu, J., Verrijn Stuart, M.H., Mihăilă, S.M., Vernooij, R.W.M., Masereeuw, R., Gerritsen, K.G.F. Animal Models for Studying Protein-Bound Uremic Toxin Removal—A Systematic Review. International Journal of Molecular Sciences (2023), 24(17), 13197. Link to paper.
  • Faria, J., Ahmed, S., Stamatialis, D., Verhaar, MC., Masereeuw, R., Gerritsen, K.G.F, Mihăilă, S.M. Bioengineered kidney tubules efficiently clear uremic toxins in experimental dialysis conditions. International Journal of Molecular Sciences (2023), 24(15), 12435. Link to paper.
  • Hernandez Pichardo, A., Littlewood, J., Taylor, A., Wilm, B., Levy, R., Murray, P. Multispectral optoacoustic tomography is more sensitive than micro-computed tomography for tracking gold nanorod labelled mesenchymal stromal cells. Journal of Biophotonics (2023), e202300109. Link to paper.
  • Calcat-i-Cervera, S., Rendra, E., Scaccia, E., Amadeo, F., Hanson, V., Wilm, B., Murray, P., O’Brien, T., Taylor, A., Bieback, K. Harmonised culture procedures minimise but do not eliminate mesenchymal stromal cell donor and tissue variability in a decentralised multicentre manufacturing approach. Stem Cell Research & Therapy (2023), 14, 120. Link to paper.
  • Amadeo, F., Hanson, V., Liptrott, N., Wilm, B., Murray, P., Taylor, A. Fate of intravenously administered umbilical cord mesenchymal stromal cells and interactions with the host’s immune system. Biomedicine & Pharmacotherapy (2023), 159, 114191. Link to paper.
  • Pichardo, A.H., Amadeo, F., Wilm, B., Lévy, R., Ressel, L., Murray, P., Sée, V. Optical tissue clearing to study the intra-pulmonary biodistribution of intravenously delivered mesenchymal stromal cells and their interactions with host lung cells.  International Journal of Molecular Sciences (2022), 23, 14171. Link to paper.
  • Ahmed, S., Sparidans, R.W., Lu, J., Mihaila, S.M., Gerritsen, K.G.F., Masereeuw, R. A robust, accurate, sensitive LC–MS/MS method to measure indoxyl sulfate, validated for plasma and kidney cells.  Biomedical Chromatography (2022), 36, e5307. Link to paper.
  • G. Valverde, M., Faria, J., Sendino Garví, E., Janssen, M.J., Masereeuw, R., Mihăilă, S.M. Organs-on-chip technology: a tool to tackle genetic kidney diseases.  Pediatric Nephrology (2022), 37, 2985–2996 Link to paper.
  • Wang, Z., Faria, J., van der Laan, L.J.W., Penning, L.C., Masereeuw, R., Spee, B. Human cholangiocytes form a polarized and functional bile duct on hollow fiber membranes.  Frontiers in Bioengineering and Biotechnology (2022), 10. Link to paper.
  • Amadeo, F., Hanson, V., Murray, P., Taylor, A. DEAE-Dextran enhances the lentiviral transduction of primary human mesenchymal stromal cells from all major tissue sources without affecting their proliferation and phenotype.  Molecular Biotechnology (2022), On-line first. Link to paper.
  • Sun, Q., Tiziana, P.Sun, Khan, A.u.M., Heuveline, V., Gretz, N. A simple optical tissue clearing pipeline for 3D vasculature imaging of the mediastinal organs in mice.   International Journal of Experimental Pathology (2021), 102, 218-227. Link to paper.
  • King, J., Mihaila, S.M., Ahmed, S., Truckenmüller, R., Giselbrecht, S., Masereeuw, R., Carlier A. The influence of OAT1 density and functionality on Indoxyl Sulfate transport in the human proximal tubule: an integrated computational and in vitro study.  Toxins (2021), 13(10), 674 Link to paper.
  • Mihajlovic, M., Krebber, M.M., Yang, Y., Ahmed, S., Lozovanu, V., Andreeva, D., Verhaar, M.C., Masereeuw R. Protein-bound uremic toxins induce reactive oxygen species-dependent and inflammasome-mediated IL-1β production in kidney proximal tubule cells.  Biomedicines (2021), 9(10), 1326 Link to paper.
  • Skovronova, R., Grange, C., Dimmucio, V., Deregibus, MC., Camussi, G., Bussolati, B. Surface marker expression in small and medium/large mesenchymal stromal cell-derived extracellular vesicles in naive or apoptotic condition using orthogonal techniques.  Cells (2021), 10(11), 2948 Link to paper.
  • Calcat-i-Cervera, S., Sanz-Nogués, C., O’Brien, T. When origin matters: properties of mesenchymal stromal cells from different sources for clinical translation in kidney disease.  Frontiers in Medicine (2021), 8, 1568. Link to paper.
  • Amadeo, F., Trivino Cepeda, K., Littlewood, J., Wilm, B., Taylor, A., Murray, P. Mesenchymal stromal cells: what have we learned so far about their therapeutic potential and mechanisms of action?  Emerging Topics in Life Sciences (2021), ETLS20210013. Link to paper.
  • Faria, J., Gerritsen, K.G.F., Nguyen, T. Q., Mihaila, S. M., Masereeuw, R. Diabetic proximal tubulopathy: can we mimic the disease for in vitro screening of SGLT inhibitors?  European Journal of Pharmacology (2021), 908, 174378. Link to paper.
  • Amadeo, F., Plagge, A., Chacko, A., Wilm, B., Hanson, V., Liptrott, N., Murray, P., Taylor, A. Firefly luciferase offers superior performance to AkaLuc for tracking the fate of administered cell therapies. European Journal of Nuclear Medicine and Molecular Imaging (2021), Online First. Link to paper.
  • Yusuf, M.M.,  Vajpayee, S., Picascia, T., Perciaccante, R., Gretz, N. An overview of non-invasive methods for transcutaneous measurements of glomerular filtration. Journal of Experimental Nephrology (2021), 2(1). Link to paper.
  • Apelt, K.; Bijkerk, R.; Lebrin, F.; Rabelink, T.J. Imaging the Renal Microcirculation in Cell Therapy. Cells (2021), 10(5), 1087. Link to paper.
  • de Haan, W., Dheedene, W., Apelt, K., Décombas-Deschamps, S., Vinckier, S., Verhulst, S., Conidi, A., Deffieux, T., Staring, M.W., Vandervoort, P., et al. Endothelial Zeb2 preserves the hepatic angioarchitecture and protects against liver fibrosis. Cardiovascular Research (2021). Online ahead of print. Link to paper.
  • Sun Q., Picascia, T., Khan, S.M., Brenna, C., Heuveline, V., Schmaus, A., Sleeman, J.P., Gretz, N. Application of ethyl cinnamate based optical tissue clearing and expansion microscopy combined with retrograde perfusion for 3D lung imaging. Experimental Lung Research (2020). On-line ahead of print. Link to paper.
  • Brenna, C., Khan, A. M., Picascia, T., Sun, Q., Heuveline, V., Gretz N. New technical approaches for 3D morphological imaging and quantification of measurements The Anatomical Record (2020), 303, 2702-2715. Link to paper.
  • Mihaila, S. M., Faria, J., Stefens, M. F. J., Stamatialis, D., Verhaar, M. C., Gerritsen, K. G. F., Masereeuw R. Drugs Commonly Applied to Kidney Patients May Compromise Renal Tubular Uremic Toxins Excretion Toxins (Basel) (2020), 12(6), 391. Link to paper.
  • Rendra, E., Scaccia, E., Bieback, K. Recent advances in understanding mesenchymal stromal cells. F1000Research (2020), 9, 156. Link to paper.
  • Gebara, N., Rossi, A., Skovronova, R., Mariam Aziz, J., Asthana, A., Bussolati, B. Extracellular Vesicles, Apoptotic Bodies and Mitochondria: Stem Cell Bioproducts for Organ Regeneration. Current Transplantation Reports  (2020), 7, 105. Link to paper.
  • Collino, F., Lopes, J. A., Tapparo, M., Tortelote, G. G., Kasai-Brunswick, T. H., Lopes, G., Almeida, D. B., Skovronova, R., Wendt, C., Miranda, K. R., Bussolati, B., Vieyra, A., Lindoso, R. S. Extracellular Vesicles Derived from Induced Pluripotent Stem Cells Promote Renoprotection in Acute Kidney Injury Model. Cells (2020), 9(2), 453. Link to paper.

• • Grange, C., Skovronova, R., Marabese, F., Bussolati, B. Stem Cell-Derived Extracellular Vesicles and Kidney Regeneration. Cells (2019), 8(10), 1240. Link to paper.

• • Faria, J., Ahmed, S., Gerritsen, K.G.F., Mihaila, S.M., Masereeuw R. Kidney-based in vitro models for drug-induced toxicity testing.  Archives of Toxicology (2019). Link to paper.